Todd ChappellM.B.A., Chief Executive Officer
Todd Chappell is the Chief Executive Officer of Perceptive Navigation, LLC. Mr. Chappell has fifteen years of experience with early-stage, venture-backed biotechnology companies. Most recently, he managed a portfolio of start-up pharmaceutical and medical device companies as an Entrepreneur-in-Residence (EIR) at BioHealth Innovation, Inc.In that role, he also served as the first EIR at the National Institutes of Health (NIH), where he worked with scientists to identify, develop and license commercially relevant technologies.
From 2009 to 2012, Todd ran Shape Pharmaceuticals, Inc., a portfolio company of HealthCare Ventures, LLC, where he oversaw all day-to-day operations involved in the development of a novel HDAC inhibitor for Cutaneous-T-Cell-Lymphoma through to a human proof-of-concept study. Shape was sold to TetraLogic Pharmaceuticals in 2014 and a Phase 2 clinical study has initiated. Prior to Shape, Mr. Chappell was at CombinatoRx Inc. for eight years and served as Director of New Products. In that role, he oversaw early-stage product development and product strategy across a range of therapeutic areas including inflammation, infectious disease, dermatology, oncology, and ophthalmology.
Mr. Chappell directly led the advancement of three programs from assay stage into human clinical studies. Mr. Chappell is a co-inventor on over 10 product patents. He holds a B.S. from University of California at Los Angeles and a M.B.A. from Boston University.
Mike ZipparoPh.D., Ultrasound Engineer
Dr. Zipparo has over 30 years of experience in ultrasound array and imaging technology. He previously worked for TETRAD, at one time the world’s largest OEM array manufacturer. He then directed R&D at W.L. Gore, another ultrasound technology company. He has particular expertise in catheter based ultrasound and will be invaluable in getting Vu-Path to market. His responsibilities include iterative design of the transducer including in-vitro and in-silico testing, help with decisions on final clinical design and oversee manufacturing design and third-party OEM supplier evaluation.
Chris DykesB.S., Design Engineer
Mr. Dykes is an engineer with over 20 years of expertise and experience with medical device design and fabrication. He has previously worked in product development and design with several large publicly traded biomedical companies. His expertise is in catheter design, plastics, ergonomics and mechanical testing. Most recently, Mr. Dykes held a position at GE Medical as a Marketing Product Manager for Infant Care microprocessor controlled thermoregulation microenvironments.
Pei ZhangPh.D., Research Engineer
Dr. Zhang has over 20 years experience with biomedical engineering with a significant amount of expertise related to evaluation of various ultrasound technologies. Dr. Zhang has independently performed large animal studies using various imaging modalities and assisted in clinical studies of novel medical devices. She has extensive experience with design, development and testing of novel devices in the pre-clinical and clinical settings. Dr. Zhang’s responsibilities includeperformingin-house testing and coordinating ultrasound machine programming, transducer development, pre-clinical testing and clinical trials.
Theodore P. AbrahamM.D., Perceptive Founder
Dr. Abraham is currently The Meyer Friedman Distinguished Professor of Medicine at University of California in San Francisco where he is Clinical Chief of Cardiology and Director of Echocardiography. Until July 2017 he was Professor of Medicine, and Radiology and Radiologic Service and Associate Dean for Research at Johns Hopkins University. He was also Director of Echocardiography and Director Johns Hopkins HCM Center of Excellence. He is a board certified clinical cardiologist with advanced training in ultrasound.
He has been involved in ultrasound research funded by the NIH and industry for 20 years and has peer-reviewed publications in almost all major cardiac ultrasound technologies, including transthoracic and transesophageal echocardiography, three-dimensional echocardiography, contrast echocardiography, tissue Doppler and strain echocardiography, and small animal imaging. Dr. Abraham is an active clinical echocardiographer and started echo-guided pericardiocentesis at Johns Hopkins.
As President and CEO, Southworth shepherded the medical-device company CircuLite from its founding in 2004 to its successful exit in late 2013. The developer and manufacturer of circulatory-support active implantable devices for heart failure was acquired by HeartWare for $30 million upfront and up to $320 million in milestone payments over ten years. Prior to CircuLite, Southworth served in key executive roles at Datascope (1999-2004), Boston Scientific (1996-1999), and other prominent health technology companies. In these roles Southworth managed international businesses in major world markets including having been based in Europe. He earned his MBA (Business Management) and BA (Business Administration) from Fairleigh Dickinson University.
Dr. Wilson has dedicated his professional life to developing new methods for diagnosing and treating heart disease, and to training new physicians. He is presently Professor of Medicine (Interventional Cardiology), Chief of Clinical Cardiology and the Fred C. and Katherine B. Andersen Foundation Chair in Adult Clinical Cardiology at the University of Minnesota. Dr. Wilson is a graduate of the University of Iowa College of Medicine, Dr. Wilson completed his residency at the University of Texas Health Science Center at San Antonio and his cardiology fellowship at the University of Iowa.
Dr. Wilson’s investigative career initially focused on coronary physiology in humans. He developed the first catheter for the selective measure of coronary blood flow in humans, and described the effects of atherosclerosis and transplantation on coronary blood flow. He also first identified reinnervation of the transplanted human heart and its effects on cardiac function. Later, Dr. Wilson developed semi-computerized injection systems for coronary angiography that are used annually for millions of patients.
Dr. Wilson’s present research focus is the development of a prosthetic heart valve that can be inserted through a small catheter, eliminating the need for open-heart valve surgery. This device is now in human clinical trials. Dr. Wilson holds numerous patents for cardiovascular treatment devices. The National Institute of Health, the American Heart Association, and private individuals have supported his work. Dr. Wilson serves on the editorial board of the Journal of the American College of Cardiology.
After attending Northwestern University Medical School, Dr. Rothstein became one of the first academically trained Emergency Physicians in the country. After his residency at the University of Chicago, Dr. Rothstein stayed on the faculty there as the residency director. In 1979, Dr. Rothstein became Chairman of the Department of Emergency Medicine at Harbor/ UCLA Medical Center and an Associate Professor of medicine. During his academic career, Dr. Rothstein published over 40 papers, edited a textbook in Emergency Medicine, and became a Director for the American Board of Emergency Medicine. As part of the Board, Dr. Rothstein wrote and edited both the written certification and recertification examinations and was an oral examiner for 30 years.
Dr. Rothstein moved to Maryland to become chair of Emergency Medicine at Suburban Hospital where he has practiced for the past 25+ years. Since arriving in Maryland, Dr. Rothstein has held clinical faculty positions at the Uniformed Services University for the Health Sciences, Georgetown University Medical School and George Washington University Medical School. Additionally, he was co-founder of Just Write, a company that developed a digital pen based electronic medical record for Emergency Physicians, used on over 2 million patients. In 2010, Dr. Rothstein was appointed to his current position as Vice President for Medical Affairs at Suburban Hospital, now part of Johns Hopkins Medicine.
Steven Lester, MD is a practicing Cardiologist in Scottsdale, AZ. Dr. Lester graduated from University of Toronto Faculty of Medicine in 1991 and has been in practice for 25 years. Dr. Lester also specializes in Internal Medicine. He currently practices at Mayo Clinic and is affiliated with Mayo Clinic Hospital.
Christos GeorgiadesM.D., Ph.D.
Dr. Georgiades is an interventional radiologist and Associate Professor of Radiology and Radiological Science at Johns Hopkins Hospital. He has over 20 years of experience in the field of medicine and graduated from Boston University School of Medicine with his medical degree in 1997.